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Otibiotic Ointment – It is antibacterial, an anti-inflammatory and an antifungal. It is used to treat acute or chronic canine otitis externa outer ear infections when caused by yeast or bacteria susceptible to gentamicin.
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Otibiotic Ointment for Dogs Ears is a combination of gentamicin, betamethasone, and clotrimazole used in dogs’ ears. Each gram of Otibiotic Ointment consists of gentamicin sulfate USP equal to 3 mg gentamicin base; betamethasone valerate, USP equal to 1 mg betamethasone; and 10 mg clotrimazole, USP in a mineral oil-based system enclosed by a plasticized hydrocarbon gel.
Otibiotic ointment for Dogs Ears – Ingredients
Gentamicin, betamethasone and clotrimazole are the major three ingredients:
Ingredient 1 – Gentamicin
Gentamicin sulfate is an aminoglycoside antibiotic dynamic against a large variety of pathogenic gram-negative and gram-positive bacteria. While performing vitro tests, it has been proven that gentamicin is bactericidal (kills bacterias). It also acts by reducing normal protein combination in vulnerable microorganisms. Gentamicin is particularly dynamic against the organisms usually isolated from canine ears such as Staphylococcus aureus, other Staphylococcus spp., Pseudomonas aeruginosa, Proteus spp., and Escherichia coli.
Ingredient 2 – Betamethasone
Betamethasone valerate is an artificial adrenocorticoid for dermatologic use. It is related to prednisolone and has a high degree of corticosteroid activity and also a small degree of mineralocorticosteroid activity. Betamethasone valerate, the 17-valerate ester of betamethasone provides anti-inflammatory and anti-itching activity in the relevant management of corticosteroid-responsive otitis externa (passage of the outer ear). It is possible to absorb relevant corticosteroids from normal, intact skin. Inflammation can increase percutaneous absorption. Once absorbed through the skin, relevant corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.
Ingredient 3 – Clotrimazole
Clotrimazole is a common antifungal agent that is useful for the treatment of dermal infections due to various types of pathogenic dermatophytes and yeasts. The main deed of clotrimazole is against dividing and growing of organisms.
In vitro test, the otitis externa infected with Malassezia pachydermatis, 1% clotrimazole included in the gentamicin, betamethasone and clotrimazole ointment was effective both microbiologically and clinically, lessening of exudates odor and swelling.
Gentamicin-Betamethasone-Clotrimazole: These three active ingredients in Otibiotic Ointment (gentamicin-betamethasone-clotrimazole) have antibacterial, anti-inflammatory, and antifungal activity. In microbiologically effectiveness studies, the compatibility and additive effect of each of these components were confirmed. In clinical field studies, gentamicin-betamethasone-clotrimazole was confirmed to be effective in the treatment of otitis externa related to bacteria and Malassezia pachydermatis.
Otibiotic Ointment for Dogs (gentamicin sulfate USP, betamethasone valerate, USP and clotrimazole, USP ointment) reduces discomfort, redness, swelling, exudates, and odor, and exercises a strong antimicrobial effect.
Otibiotic Ointment Side Effects
Gentamicin: While aminoglycosides are absorbed poorly from skin, intoxication may occur when aminoglycosides are applied topically for an extended time period to large wounds, burns, or any uncover skin, particularly if there is a renal deficiency. All aminoglycosides have the possibility to produce reversible and irreversible vestibular, cochlear, and renal toxicity.
Betamethasone: Side effects such as weight loss, loss of appetite, polydipsia, and polyuria are seen after the use of parenteral or systemic synthetic corticosteroids in dogs. Vomiting and diarrhea (rarely bloody) are also seen in dogs and cats.
Clotrimazole: Erythema, stinging, blistering, peeling, edema, pruritus, urticaria, and general irritation of the skin not present before therapy is seen occasionally in humans due to the use of clotrimazole.
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Otibiotic Ointment for Dogs Ears is an ear medicine that includes an antibacterial, anti-inflammatory and antifungal substance that is useful for treating dogs for severe or chronic outer ear infections. The cause of ear infection can be yeast or bacteria vulnerable to gentamicin.
Otibiotic ointment for Dogs Ears – Contraindications
If an allergic reaction occurs, we should immediately cease the treatment and should start another suitable treatment. Also, stop the usage of drugs that encourage ototoxicity. We should not use it for dogs with eardrums damage.
The use of Otibiotic Ointment for Dogs may cause deafness or partial hearing loss in a small number of sensitive dogs. Usually, the hearing deficit due to this is temporary.
If we detect any hearing or vestibular abnormality during the treatment, discontinue use of Otibiotic Ointment immediately and flush the ear canal comprehensively with a non-ototoxic solution.
Corticosteroids are given to dogs, rabbits, and rodents during pregnancy normally result in cloven palate in young. Another inborn abnormality including forelegs deformity, phocomelia, and anasarca is seen in young dogs as their mothers had corticosteroids during pregnancy.
Clinical and experimental information proves that corticosteroids are given orally or parent rally to animals during the last trimester of pregnancy encourages the first stage of parturition.
Precautions Of Otibiotic Ointment for Dogs Ears
Identification of the infecting organisms using either a microscopic or any other accurate mode as suitable. We should determine the antibiotic vulnerability of the pathogenic organism(s) before using Otibiotic Ointment.
If overgrowth of inaccessible bacteria, fungi, or yeasts occurs and/or hypersensitivity develops, we should immediately cease the current treatment and adopt any other suitable curing therapy.
Use of Otibiotic Ointment (gentamicin-betamethasone-clotrimazole ointment) beyond 7 days or irregular doses may result in a delay in wound healing.
Avoid oral ingestion as various adverse reactions are seen due to some relevant corticosteroid preparations. The dog should be under close observation for any unusual signs of adrenocorticoid overdosage such as sodium retention, potassium loss, fluid retention, weight gain, polydipsia and/or polyuria. Prolonged use or overdosage may result in adverse anti effects.
Check the external ear canal thoroughly, before instilling any medication into the ear. Ensure that it does not rupture the tympanic membrane to avoid the likelihood of transmitting the infection to the middle ear.
Clinical and safety studies with Otibiotic Ointment have revealed a wide safety margin at the recommended dose level in dogs.
- Otibiotic Ointment (gentamicin-betamethasone-clotrimazole ointment) is available in 7.5 ml, 10 gram, 15 ml and 25 gram tubes and 15 gram and 215 ml plastic bottles.
- Store them between 2° and 25°C (36° and 77°F).
- Shake well before use when using the 215 ml bottle.
- Keep out of the reach of children.
Dosage and Administration – Otibiotic ointment for dogs ears
The external ear should be comprehensively cleaned and dried before starting the treatment. Remove foreign material, debris, coated exudates, etc., with suitable non-irritating ointment. Excessive hair should be removed from the treatment area.
After confirming that the eardrum is intact:
- Instill 4 drops (2 drops from the 215 g bottle) of Otibiotic Ointment (gentamicin-betamethasone-clotrimazole ointment) twice daily into the ear canal of dogs weighing less than 30 lbs.
- Instill 8 drops (4 drops from the 215 g bottle) twice daily into the ear canal of dogs weighing 30 lbs or more.
Continue this treatment for 7 consecutive days.
Quadritop ointment 15 ml
The quadritop ointment 15 ml is a medication available in the medium-sized tubes. This quadritop ointment, 15 ml can be used to relieve the symptoms caused by bacterial fungal, parasitic infections and also that is caused by allergies or dry skin. The symptoms are minimized by the local application of the quadritop ointment at the affected areas. It is also able to prevent further infections as well.
Apply the quadritop ointment at the affected areas after thoroughly cleaning it with an antiseptic lotion and drying it. Make sure to remove any residue of the infections before applying the ointment.
Quadritop ointment, 15 ml is also useful in treating otitis and apply or rather drop the medication into the ear canal.