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Otibiotic Ointment for Dogs Ears is a combination of gentamicin, betamethasone, and clotrimazole used in dogs’ ears. Each gram of Otibiotic Ointment consists of gentamicin sulfate USP equal to 3 mg gentamicin base; betamethasone valerate, USP equal to 1 mg betamethasone; and 10 mg clotrimazole, USP in a mineral oil-based system enclosed by a plasticized hydrocarbon gel.
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Otibiotic ointment for Dogs Ears – Ingredients
Gentamicin, betamethasone and clotrimazole are the major three ingredients:
Ingredient 1 – Gentamicin
Gentamicin sulfate is an aminoglycoside antibiotic dynamic against a large variety of pathogenic gram-negative and gram-positive bacteria. While performing vitro tests, it has been proven that gentamicin is bactericidal (kills bacterias). It also acts by reducing normal protein combination in vulnerable microorganisms. Gentamicin is particularly dynamic against the organisms usually isolate from canine ears such as Staphylococcus aureus, other Staphylococcus spp., Pseudomonas aeruginosa, Proteus spp., and Escherichia coli.
Ingredient 2 – Betamethasone
Betamethasone valerate is an artificial adrenocorticoid for dermatologic use. It is related to prednisolone and has a high degree of corticosteroid activity and also a small degree of mineralocorticosteroid activity. Betamethasone valerate, the 17-valerate ester of betamethasone provides anti-inflammatory and anti-itching activity in the relevant management of corticosteroid-responsive otitis externa (passage of the outer ear). It is possible to absorb relevant corticosteroids from normal, intact skin. Inflammation can increase percutaneous absorption. Once absorbed through the skin, relevant corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.
Ingredient 3 – Clotrimazole
Clotrimazole is a common antifungal agent that is useful for the treatment of dermal infections due to various types of pathogenic dermatophytes and yeasts. The main deed of clotrimazole is against dividing and growing of organisms.
In vitro test, the otitis externa infected with Malassezia pachydermatis, 1% clotrimazole included in the gentamicin, betamethasone and clotrimazole ointment was effective both microbiologically and clinically, lessening of exudates odor and swelling.
Gentamicin-Betamethasone-Clotrimazole: These three active ingredients in Otibiotic Ointment (gentamicin-betamethasone-clotrimazole) have antibacterial, anti-inflammatory, and antifungal activity. In microbiologically effectiveness studies, the compatibility and additive effect of each of these components were confirmed. In clinical field studies, gentamicin-betamethasone-clotrimazole was confirmed to be effective in the treatment of otitis externa related with bacteria and Malassezia pachydermatis.
Otibiotic Ointment for Dogs (gentamicin sulfate USP, betamethasone valerate, USP and clotrimazole, USP ointment) reduces discomfort, redness, swelling, exudates, and odor, and exercises a strong antimicrobial effect.
Otibiotic Ointment Side Effects
Gentamicin: While aminoglycosides are absorbed poorly from skin, intoxication may occur when aminoglycosides are applied topically for an extended time period to large wounds, burns, or any uncover skin, particularly if there is a renal deficiency. All aminoglycosides have the possibility to produce reversible and irreversible vestibular, cochlear, and renal toxicity.
Betamethasone: Side effects such as weight loss, loss of appetite, polydipsia, and polyuria are seen after the use of parenteral or systemic synthetic corticosteroids in dogs. Vomiting and diarrhea (rarely bloody) are also seen in dogs and cats.
Clotrimazole: Erythema, stinging, blistering, peeling, edema, pruritus, urticaria, and general irritation of the skin not present before therapy is seen occasionally in humans due to the use of clotrimazole.More Details »
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Otibiotic Ointment for Dogs Ears is an ear medicine that includes an antibacterial, anti-inflammatory and antifungal substance that is useful for treating dogs for severe or chronic outer ear infections. The cause of ear infection can be yeast or bacteria vulnerable to gentamicin.
Otibiotic ointment for Dogs Ears - Contraindications
Precautions Of Otibiotic Ointment for Dogs Ears
Dosage and Administration - Otibiotic ointment for dogs ears
Quadritop ointment 15 ml
Originally posted 2014-07-02 08:35:27.